Japanese encephalitis (JE) vaccines

Routine vaccination:
  • Recommended only for individuals living in endemic areas till 18 years of age
  • The vaccine should be offered to the children residing in rural areas only and those planning to visit endemic areas (depending upon the duration of stay)
  • Three types of new generation JE vaccines are licensed in India : one, live attenuated, cell culture derived SA-14-14-2, and two inactivated JE vaccines, namely 'vero cell culture-derived SA 14-14-2 JE vaccine' (JEEV® by BE India) and 'vero cell culture-derived, 821564XY, JE vaccine' (JENVAC® by Bharat Biotech)
  • Live attenuated, cell culture derived SA-14-14-2:
    • Minimum age: 8 months;
    • Two dose schedule, first dose at 9 months along with measles vaccine and second at 16 to 18 months along with DTP booster
    • Not available in private market for office use
  • Inactivated cell culture derived SA-14-14-2 (JEEV® by BE India) :
    • Minimum age: 1 year (US-FDA: 2 months)
    • Primary immunization schedule: 2 doses of 0.25ml each administered intramuscularly on days 0 and 28 for children aged >= 1 to <= 3 years
    • 2 doses of 0.5 ml for children >3years and adults aged ≥18 years
    • Need of boosters still undetermined
  • Inactivated Vero cell culture-derived Kolar strain, 821564XY, JE vaccine (JENVAC® by Bharat Biotech)
    • Minimum age: 1 year
    • Primary immunization schedule: 2 doses of 0.5 ml each administered intramuscularly at 4 weeks interval
    • Need of boosters still undetermined.
Catch up vaccination:
  • All susceptible children up to 18 yrs should be administered during disease outbreak/ahead of anticipated outbreak in campaigns