Pneumococcal conjugate vaccines (PCVs)

Routine vaccination:
  • Minimum age: 6 weeks
  • Both PCV10 and PCV13 are licensed for children from 6 weeks to 5 years of age (although the exact labeling details may differ by country). Additionally, PCV13 is licensed for the prevention of pneumococcal diseases in adults >50 years of age
  • Primary schedule (For both PCV10 and PCV13): 3 primary doses at 6, 10, and 14 weeks with a booster at age 12 through 15 months.
Catch-up vaccination:
  • Administer 1 dose of PCV13 or PCV10 to all healthy children aged 24 through 59 months who are not completely vaccinated for their age.
  • For PCV 13: Catch up in 6-12 months: 2 doses 4 weeks apart and 1 booster; 12-23 months: 2 doses 8 weeks apart; 24 mo & above: single dose
  • For PCV10: Catch up in 6-12 months: 2 doses 4 weeks apart and 1 booster; 12 months to 5 years: 2 doses 8 weeks apart
  • Vaccination of persons with high-risk conditions:
    • PCV and pneumococcal polysaccharide vaccine [PPSV] both are used in certain high risk group of children.
    • For children aged 24 through 71 months with certain underlying medical conditions, administer 1 dose of PCV13 if 3 doses of PCV were received previously, or administer 2 doses of PCV13 at least 8 weeks apart if fewer than 3 doses of PCV were received previously.
    • A single dose of PCV13 may be administered to previously unvaccinated children aged 6 through 18 years who have anatomic or functional asplenia (including sickle cell disease), HIV infection or an immunocompromising condition, cochlear implant or cerebrospinal fluid leak.
    • Administer PPSV23 at least 8 weeks after the last dose of PCV to children aged 2 years or older with certain underlying medical conditions.