Typhoid vaccines

Routine vaccination:

• Both Vi-PS conjugate and Vi-PS (polysaccharide) vaccines are available
• Minimum ages:
  • Vi-PS conjugate: 6 months
  • Vi-PS (polysaccharide) vaccines: 2 years
• Vaccination schedule:
  • Typhoid conjugate vaccines (Vi-PS):
    • Single dose at 6-9 months
  • Vi-PS (polysaccharide) vaccines: Single dose at 2 years; revaccination every 3 years
• No evidence of hypo-responsiveness on repeated revaccination of Vi-polysaccharide vaccine so far. However, typhoid conjugate vaccine should be preferred over Vi- PS vaccine

Catch-up vaccination:

• Recommended throughout the adolescent period, i.e. up to 18 years of age
• Vi conjugate typhoid vaccine should be preferred over Vi-PS vaccine wherever feasible
• The need and exact timing of the booster doses are not yet determined.