Typhoid vaccines

Routine vaccination:
  • Both Vi-PS conjugate and Vi-PS (polysaccharide) vaccines are available
  • Minimum ages:
     
    • Vi-PS conjugate (Typbar-TCV® ): 6 months; o Vi-PS conjugate (Pedatyph®): 6 months;
    • Vi-PS (polysaccharide) vaccines: 2 years
  • Vaccination schedule:
    • Typhoid conjugate vaccines (Vi-PS):
      • Typbar-TCV®: Single dose at 9-12 through 23 months followed by a booster at 2 years of age
      • Pedatyph® : Single dose at 9-12 through 23 months followed by a booster at 2 years of age
    • Vi-PS (polysaccharide) vaccines: Single dose at 2 years; revaccination every 3 years;
  • Currently, two typhoid conjugate vaccines, Typbar-TCV® and PedaTyph® are available in Indian market;
  • An interval of at least 4 weeks with the MMR vaccine should be maintained while administering Typbar-TCV® and PedaTyph® vaccines
  • Typhoid revaccination every 3 years, if Vi-polysaccharide vaccine is used
  • No evidence of hypo-responsiveness on repeated revaccination of Vi-polysaccharide vaccine so far. However, typhoid conjugate vaccine should be preferred over un-conjugated Vi- PS vaccine
Catch-up vaccination:
  • Recommended throughout the adolescent period, i.e. up to 18 years of age
  • Vi conjugate typhoid vaccine should be preferred over Vi-PS vaccine wherever feasible
  • The need and exact timing of the booster doses are not yet determined.